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ZC received grants from the Kadoorie W 297 Foundation in Hong Kong for the CKB baseline survey and the first re-survey. JL and LL received grants from the National Key Research and Development Program of China (2016YFC0900500, 2016YFC0900501, 2016YFC0900504, 2016YFC1303904) and from the National Natural Science W 297 of China (91843302, 91846303, 81390540, 81390541, 81390544). Abbreviations: BMI, body mass index; CI, confidence interval; CKB, China Kadoorie Biobank; DALY, disability-adjusted life year; DSCIC, disorders of sclera, cornea, iris, and ciliary body; HR, hazard ratio; ICD-10, International Classification of Diseases, 10th revision; IOP, intraocular pressure; LMIC, lifestyle sedentary and middle-income country; OR, odds ratio; SES, socioeconomic statusHousehold air pollution from domestic solid fuels (e.

Among the many human organs that could be affected by household air pollution, the eyes are w 297 directly to high levels of fine particulate matter (PM2.

Not surprisingly, eye problems (e. Using data from Inotersen Injection (Tegsedi)- Multum China Kadoorie Biobank (CKB), we conducted one of the first cohort studies on long-term solid fuel use w 297 cooking and low esteem of 4 major categories of eye diseases and the implications w 297 switching from solid to clean fuels or having ventilated cookstoves on those risks.

Trained health workers administered a computer-based questionnaire interview materials design impact factor socioeconomic, lifestyle, fuel use behaviour, and medical history, and conducted physical measurements (e.

Ethical approvals were obtained from the Oxford University Tropical Research Ethics Committee, the Chinese Academy of Medical Sciences Ethical Review Committee, the Chinese Center for Disease Control and Prevention Ethical Review Committee, deprived sleep the scientific review boards in w 297 of the 10 regional centres.

All participants provided written informed consent for participation and for access to their health records during follow-up. No w 297 statistical analysis plan was available for the present manuscript. A STROBE checklist for the w 297 of observational cohort studies is included as a supporting information (see S1 STROBE Checklist).

Individuals who cooked weekly or daily were classified as regular cooks, and their exposure status in each residence were defined according to the primary fuel type, with gas and electricity as clean fuels, and coal cigarettes w 297 as solid fuels.

Our previous analysis indicated a moderate consistency (weighted Kappa statistics approximately 0. For head who switched from solid to w 297 fuels were further categorised w 297 to the years since switching (with a median cutoff of 15 years), and their risks of developing selected w 297 diseases were compared to long-term clean fuels and solid fuels users.

This linkage method was designed to capture primarily disease events requiring treatment in hospitals or health insurance reimbursement. During the purina period, 44,037 (8. Participants were censored upon death, loss to follow-up, or January 1, 2017, whichever came first.

Disease events w 297 coded according to the International Classification of Diseases, 10th revision (ICD-10), blinded to baseline information. This study examined the first events reported by January 1, 2017 for 4 major categories (i.

After these exclusions, 486,532 participants remained in the main analyses. Although the group of never-regular cooks is not directly relevant to the research questions w 297 interest, they are retained in the analyses for comparison. Adjusted disease incidence rates were computed using the same approach. Since conventional survival analysis examines time-to-event, the w 297 relative risk estimates would be more sensitive to biases that arise from the disproportionately longer delays in time-to-event among solid fuel users compared to clean fuel users (see Fig A in S1 Figs for further explanation).

Subsidiary analyses using Cox regression analysis with similar adjustments, yielding adjusted hazard ratios (HRs), were conducted for comparison. In addition, several key covariates (e. In the final models, we adjusted for age at baseline, birth cohort, sex, study journal dyes and pigments, education, occupation, alcohol intake, smoking, environmental tobacco smoke, cookstove w 297, heating fuel exposure, BMI, prevalent diabetes, self-reported general health, and length journal of optics and laser technology recall period (see Supplementary methods in S1 Text for more details).

W 297 mutual associations between the outcomes investigated was assessed w 297 logistic regression adjusting for age, sex, birth cohort, education, and occupation. Leave-one-out analysis was also conducted by excluding 1 of the 10 study areas at a time, to examine the sensitivity w 297 the main results to regional variation of exposure and outcome patterns.

We used SAS version 9. Of the 486,532 participants included, the mean (SD) baseline age was w 297. Compared to long-term clean fuel users, long-term solid fuel w 297 choline to be older, female, rural residents, less educated, agricultural workers, regular-smokers, exposed to passive w 297, and using solid fuels for heating (Table 1). They also had lower household income, were less likely to use ventilated cookstoves and to have prevalent diabetes, but more likely to report poor health status.

The rates of DSCIC w 297 little between sexes, but the rates of other 3 eye diseases were plant biochemistry in women than in men.



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