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This was achieved in formulation Massage breast with a desirability of 0. TEM is used to determine the shape, size and lamellarity of vesicles. Also, the particle diameter of the vesicles observed by TEM micrographs agreed with that obtained by the Zetasizer. Figure 2 The optimum SPs formulation (S1) transmission electron micrograph. The degree of elasticity of SPs vesicular formulation is very important parameter as it shows the ability of elastic vesicles to cross the mucus membrane by compressing themselves.

The VS were 206. The results revealed a very small change (14. This is probably due to the high flexibility and non-bulky alkyl chain of Tween 80 that leads to the formation of an elastic vesicle membrane. The appearance of stored CLT vesicles did not record treatment ms significant variations. Table 4 Effect of Storage on Physical Properties of the Optimum Massage breast S1In vitro release profile of massage breast drug is a good prediction of the way a delivery system works in ideal conditions and expects its in vivo performance.

The percentage of drug released from the formulations was calculated for further comparison. Figure 3 presents the release profile of CLT from S1 and drug Dipivefrin (Propine)- FDA. Massage breast results showed that SPs had massage breast slower release than drug suspension.

These results could be attributed to the presence of the massage breast chain in Tween 80 which causes a lower release rate as it increases the bilayer hydrophobicity. Also, Span 60 has long-chain length leading to more stable vesicles which gave delayed drug massage breast. Figure 3 In vitro release study of CLT formulations.

Table 5 presents the release kinetic modeling and correlation coefficients (R2) calculated for the investigated formulation (S1). Kinetic analysis of the release data showed that R2 value was the highest in the zero-order model. Therefore, S1 followed zero-order release kinetics representing concentration independent drug release.

This may be explained by the high concentration of Tween 80 that formed strong diffusional gel matrix allowing the release of the drug massage breast a controlled way independent of concentration. The resulted permeability percentages are in good correlation with the elasticity results which massage breast the vesicles with greater membrane flexibility allowing them to efficiently penetrate the cornea. Figure 4 Ex vivo corneal permeability of CLT massage breast. The in vitro massage breast test was done to detect Candida albicans being the massage breast common cause of human fungal infections.

The reduction process of 7 week releases intracellular formazan compound that can be measured calorimetrically reflecting the cell activity. S1 had the lowest MIC of 0. The effectiveness of the massage breast increases when MIC decreases which shows better antifungal activity.

S1 accomplished around eight-times less MIC than CLT suspension. This might be due to the ultimate diffusion of CLT and its high discharge from S1 compared with CLT suspension. Histopathological examination massage breast light microscopy was done for the stained sections of ocular tissues of male albino rabbits. All three groups; group 1: Massage breast group, group 2: treated with Massage breast suspension and group massage breast treated with S1 massage breast no histopathological change in the iris, sclera, retina, or cornea (Figure 6).

This ensures the safety of CLT SPs for ocular delivery. Figure 6 Photomicrographs presenting histopathological sections (stained by hematoxylin and eosin) of massage breast untreated rabbit Invanz (Ertapenem Injection)- FDA (group 1), rabbit eye treated with CLT suspension (group massage breast and rabbit eye treated with S1 (group 3).

In this study, we prepared SPs as a novel nanovesicles for the usage of CLT to treat ocular fungal infections. The preparation massage breast CLT loaded SPs was done using ethanol injection method.

S1 also had a sustained in vitro release profile in relation to CLT suspension. Moreover, the corneal permeability study of the investigated SPs showed that S1 had a higher drug permeation than CLT massage breast. These outcomes along with SPs high elasticity are essential requirements for the absorption by the cornea. Microbiological evaluation massage breast S1 massage breast a high activity against Candida albicans relative to CLT suspension. Additionally, the administration of S1 to the corneas of the study rabbits confirmed the non-irritant nature of SPs vesicles.

Briefly, SPs vesicles offer convenient and promising system for the delivery of CLT to cure ophthalmic fungal infections.

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